Tyrosol → 2-{3-[3-(4-Fluorophenoxy)propoxy]phenyl}ethanol

HRID 467344

반응식

[F:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][CH2:8][CH2:9]Br)=[CH:4][CH:3]=1.O(CCCCBr)C1C=CC=CC=1.[OH:25][C:26]1[CH:27]=[C:28]([CH2:32][CH2:33][OH:34])[CH:29]=[CH:30][CH:31]=1.OC1C=CC(CCO)=CC=1>>[F:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][CH2:8][CH2:9][O:25][C:26]2[CH:27]=[C:28]([CH2:32][CH2:33][OH:34])[CH:29]=[CH:30][CH:31]=2)=[CH:4][CH:3]=1

참가 물질

반응물 4

HCID 10393Tyrosol

HCID 70986(4-Bromobutoxy)benzene

HCID 834043-Hydroxyphenethyl alcohol

HCID 2600041-(3-Bromopropoxy)-4-fluorobenzene

생성물 1

HCID 197556492-{3-[3-(4-Fluorophenoxy)propoxy]phenyl}ethanol수율 95%

실험 절차

By following the procedure of example 9 and using 3-(4-fluorophenoxy)propyl bromide rather than 4-phenoxybutyl bromide and 2-(3-hydroxyphenyl)ethanol rather than 2-(4-hydroxyphenyl)ethanol, the title compound was prepared.

출처 및 근거

ORD 기록: ord-ea1c9f7f47804c2da89bd5e19d938258
출처 데이터셋: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05159097

연결된 노트

불러오는 중…