Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyclohexylcarbodiimide → Boc-(D)Ala-Gly-OBzl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 3a,4,7,7a-Tetrahydro-2-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione | HCID 89529 | — |
| 반응물 | Benzyl glycinate | HCID 409140 | — |
| 반응물 | BOC-D-alanine | HCID 637606 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Boc-(D)Ala-Gly-OBzl | HCID 15567200 | — |
반응 단계
To 7.4 g H-Gly-OBzl.p-Tos-OH, 100 ml acetonitrile was added, and this was followed by cooling with ice, then 3.1 ml TEA, 3.78 g Boc-D-Ala-OH, 3.96 g HONB and 4.54 g DCC were added, and this was followed by agitation for one night. The resulting DCU was filtered, and the filtrate was concentrated, then the resulting residue was dissolved in 300 ml AcOEt. The resulting solution was washed with 4% aqueous NaHCO3 and 10% aqueous citrate, after which it was dried with Na2SO4. The dried product, after concentration, was crystallized with petroleum benzine and collected by filtration.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05159061 |
| 출처 데이터셋 | uspto-grants-1992_10 |
| ORD ID | ord-19479433fbc3461c879e4c0ae89705b2 |
| 출처 메모 | uspto-grants-1992_10 |