3-[[(S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-oxo-3-phenylpropyl]amino]propanoic acid, phenylmethyl ester → Boc-Phe-betaAla-OH

HRID 467355노트

반응식

HRID 467355 반응식
[NH:1]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C@H:2]([C:10]([NH:12][CH2:13][CH2:14][C:15]([O:17]CC1C=CC=CC=1)=[O:16])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO.[Pd]>[NH:1]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C@H:2]([C:10]([NH:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 1

HCID 136862023-[[(S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-oxo-3-phenylpropyl]amino]propanoic acid, phenylmethyl ester

생성물 1

HCID 14330680Boc-Phe-betaAla-OH

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

3.0 g Boc-Phe-βAla-OBzl was reduced in 50 ml MeOH in the presence of Pd-black as a catalyst, and this was followed by concentration; the resulting residue was dissolved in 30 ml AcOEt, after which it was crystallized with 0.80 ml CHA and collected by filtration.

후처리

  1. concentrationthis was followed by concentration
  2. dissolutionthe resulting residue was dissolved in 30 ml AcOEt
  3. customafter which it was crystallized with 0.80 ml CHA
  4. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-d9e70b58f34e47899769f70bb4eb5d14
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05159061

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