Ethyl 4,6-dichloro-4-fluoro-3-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylate → 3-(2-Carboxyethyl)-4,6-dichloro-4-fluoro-1H-indole-2-carboxylic acid

HRID 467427노트

반응식

HRID 467427 반응식
[Cl:1][C:2]1([F:24])[CH:10]=[C:9]([Cl:11])[CH:8]=[C:7]2[C:3]1=[C:4]([CH2:17][CH2:18][C:19]([O:21]CC)=[O:20])[CH:5]([C:12]([O:14]CC)=[O:13])[NH:6]2.O.O.O.[OH-].[Li+]>O1CCCC1.O>[C:19]([CH2:18][CH2:17][C:4]1[CH:5]([C:12]([OH:14])=[O:13])[NH:6][C:7]2[C:3]=1[C:2]([Cl:1])([F:24])[CH:10]=[C:9]([Cl:11])[CH:8]=2)([OH:21])=[O:20]

참가 물질

5

반응물 2

HCID 71280672Ethyl 4,6-dichloro-4-fluoro-3-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylateHCID 86677587Lithium hydroxide trihydrate

생성물 1

HCID 712808413-(2-Carboxyethyl)-4,6-dichloro-4-fluoro-1H-indole-2-carboxylic acid수율 95%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매2회

실험 절차

Ethyl 4,6-dichloro-4-fluoro-3-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylate (1.13 g, 3 mmol) was dissolved in 15 ml tetrahydrofurane (THF) with stirring at rt. Then a solution of 0.38 g of lithium hydroxide trihydrate (3 equiv.) in 15 ml water was added and the resulting mixture was let to stir at rt for 24 h. After completion of the reaction THF was removed under reduced pressure and the pH was adjusted to 4-5, and the product was extracted with diethyl ether (3×15 ml). The organic layers were dried over magnesium sulfate, filtered, and evaporated to dryness to yield a light-beige-colored solid in 95-100% yield. mp. 292-294° C. 1H-NMR (DMSO-d6) δ 2.48 (m, 2H, 2′-H); 3.48 (m, 2H, 1′-H); 7.49 (dd, 1H, 2J=6 Hz, 7-H); 11.98 (s, 1H, NH); 12.72 (b, 2H, 2CO2H). 13C-NMR (DMSO-d6) δ 20.1 (C-2′); 36.1 (C-1′); 112.5 (C-7); 113.0, 113.2, 117.6, 117.7, 121.3, 121.4 (C-5); 122.3 (C-4); 127.7 (C-6); 132.5 (C-3); 147.2 (C-3a); 149.0 (C-2); 162.5 (2′-CO2H), 173.6 (2-CO2H). LC-MS (m/z): 337 [M-NH4+]+, 320 [M]+, 318 [M]−. Purity (LC-MS): 98.6%.

후처리

  1. stirringto stir at rt for 24 h
  2. customwas removed under reduced pressure
  3. extractionthe product was extracted with diethyl ether (3×15 ml)
  4. dry with materialThe organic layers were dried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated to dryness
  7. customto yield a light-beige-colored solid in 95-100% yield

출처 및 근거

ORD 기록
ord-d322b7b9ef374976b6811d31959b331b
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623593B1

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