Ethyl isocyanate → 1-Butyl-3-ethyl-1-(4-methyl-2-oxazolyl)urea

HRID 46755노트

반응식

HRID 46755 반응식
[CH2:1]([NH:5][C:6]1[O:7][CH:8]=[C:9]([CH3:11])[N:10]=1)[CH2:2][CH2:3][CH3:4].[CH2:12]([N:14]=[C:15]=[O:16])[CH3:13]>C1C=CC=CC=1>[CH2:1]([N:5]([C:6]1[O:7][CH:8]=[C:9]([CH3:11])[N:10]=1)[C:15]([NH:14][CH2:12][CH3:13])=[O:16])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 8022Ethyl isocyanateHCID 122952262-Oxazolamine, N-butyl-4-methyl-

생성물 1

HCID 234689611-Butyl-3-ethyl-1-(4-methyl-2-oxazolyl)urea

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A solution of 2-butylamino-4-methyloxazole (15.0 g, 0.0972 mol) and ethyl isocyanate (7.6 g, 0.107 mol) in dry benzene was heated under reflux for 2 hours and then evaporated to dryness. The residual oil was dissolved in ether and the solution was washed with 2N HCl, dried and evaporated. The residue was distilled under vacuum b.p. 128° C./1.0 mm. IR 3275, 1696, 1590 cm-1.

후처리

  1. temperatureunder reflux for 2 hours
  2. customevaporated to dryness
  3. dissolutionThe residual oil was dissolved in ether
  4. washthe solution was washed with 2N HCl
  5. customdried
  6. customevaporated
  7. distillationThe residue was distilled under vacuum b.p. 128° C./1.0 mm

출처 및 근거

ORD 기록
ord-c7c7188d95c946e986f4155766643307
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175131

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