Cyclobutylamine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (3-cyclobutylcarbamoyl-1-methyl-1H-pyrazol-4-yl)-amide

HRID 467656노트

반응식

HRID 467656 반응식
[CH:1]1([NH2:5])[CH2:4][CH2:3][CH2:2]1.C[O:7][C:8]([C:10]1[C:14]([NH:15][C:16]([C:18]2[C:23]([NH:24][C:25]3[CH:26]=[N:27][CH:28]=[N:29][CH:30]=3)=[CH:22][CH:21]=[C:20]([CH:31]3[CH2:33][CH2:32]3)[N:19]=2)=[O:17])=[CH:13][N:12]([CH3:34])[N:11]=1)=O>>[CH:1]1([NH:5][C:8]([C:10]2[C:14]([NH:15][C:16]([C:18]3[C:23]([NH:24][C:25]4[CH:26]=[N:27][CH:28]=[N:29][CH:30]=4)=[CH:22][CH:21]=[C:20]([CH:31]4[CH2:33][CH2:32]4)[N:19]=3)=[O:17])=[CH:13][N:12]([CH3:34])[N:11]=2)=[O:7])[CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 75645CyclobutylamineHCID 700992004-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

생성물 1

HCID 701172576-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (3-cyclobutylcarbamoyl-1-methyl-1H-pyrazol-4-yl)-amide수율 24%

실험 절차

According to the general method described in step 5 of example 27, reaction of cyclobutylamine with 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester provided the title compound (24%) as yellow powder.

출처 및 근거

ORD 기록
ord-0c4b08db53de4ae2b416bd06f3047c76
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623866B2

반응 노트

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