Potassium Hydroxide → 2-p-Chlorophenyl-5-phenylthio-4-thiazoleacetic acid

HRID 46770노트

반응식

HRID 46770 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([S:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[C:11]([CH2:13][C:14]([O:16]CC)=[O:15])[N:12]=2)=[CH:4][CH:3]=1.[OH-].[K+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]([S:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 54037631Ethyl 2-p-chlorophenyl-5-phenylthio-4-thiazoleacetate

생성물 1

HCID 541246842-p-Chlorophenyl-5-phenylthio-4-thiazoleacetic acid수율 72.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 3.4 g of ethyl 2-p-chlorophenyl-5-phenylthio-4-thiazoleacetate in 100 ml of methanol was added 15 ml of 3 N aqueous potassium hydroxide. The mixture was stirred at room temperature for 3 hours. The solvent was distilled off under reduced pressure and water was added to the residue. The solution was acidified with hydrochloric acid. The white precipitated solid was filtered off, washed with water, dried and recrystallized from ethanol to give 2.3 g of the title compound, melting at 191°-193° C.

후처리

  1. distillationThe solvent was distilled off under reduced pressure and water
  2. additionwas added to the residue
  3. customThe white precipitated solid
  4. filtrationwas filtered off
  5. washwashed with water
  6. customdried
  7. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-7d4bf85428134dbaa864623b14535ef5
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175130

반응 노트

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