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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 467726생성일: 2026년 10월 25일

Oxolan-3-amine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(tetrahydro-furan-3-ylcarbamoyl)-pyridin-3-yl]-amide

https://huagongshe.com/reaction/467726

반응식

참여 물질

역할이름HCID투입량
반응물Oxolan-3-amineHCID 3365553—
반응물3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acidHCID 70098928—
생성물6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(tetrahydro-furan-3-ylcarbamoyl)-pyridin-3-yl]-amideHCID 5854827196%

반응 단계

According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with 3-aminotetrahydro-furan, providing the title compound as yellow solid (96%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08623866B2
출처 데이터셋uspto-grants-2014_01
ORD IDord-a77e728767834f17a18b819d27297762
출처 메모uspto-grants-2014_01