Oxetan-3-amine hydrochloride → HCID 58548217, 화합물

HRID 467729

반응식

HRID 467729 반응식
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:12][C:13]3[CH:21]=[N:20][CH:19]=[CH:18][C:14]=3[C:15](O)=[O:16])=[O:11])[C:7]([NH:22][C:23]3[CH:24]=[N:25][CH:26]=[N:27][CH:28]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1.Cl.[O:30]1[CH2:33][CH:32]([NH2:34])[CH2:31]1>>[O:30]1[CH2:33][CH:32]([NH:34][C:15]([C:14]2[CH:18]=[CH:19][N:20]=[CH:21][C:13]=2[NH:12][C:10]([C:8]2[C:7]([NH:22][C:23]3[CH:24]=[N:25][CH:26]=[N:27][CH:28]=3)=[N:6][CH:5]=[C:4]([CH:1]3[CH2:3][CH2:2]3)[N:9]=2)=[O:11])=[O:16])[CH2:31]1

참가 물질

3

반응물 2

HCID 23062080Oxetan-3-amine hydrochlorideHCID 70098928HCID 70098928, 화합물

생성물 1

HCID 58548217HCID 58548217, 화합물수율 58%

실험 절차

According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with oxetan-3-amine hydrochloride, providing the title compound as yellow solid (58%).

출처 및 근거

ORD 기록
ord-bbba5cc4a98a4f4ea8f6cd009573e343
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623866B2

연결된 노트

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