N-(2-Hydroxy-2-methylpropyl)-N,1-dimethyl-4-nitro-1H-pyrazole-3-carboxamide → 4-Amino-N-(2-hydroxy-2-methylpropyl)-N,1-dimethyl-1H-pyrazole-3-carboxamide

HRID 467731노트

반응식

HRID 467731 반응식
[OH:1][C:2]([CH3:18])([CH3:17])[CH2:3][N:4]([CH3:16])[C:5]([C:7]1[C:11]([N+:12]([O-])=O)=[CH:10][N:9]([CH3:15])[N:8]=1)=[O:6]>C(O)C.[Pd]>[NH2:12][C:11]1[C:7]([C:5]([N:4]([CH2:3][C:2]([OH:1])([CH3:17])[CH3:18])[CH3:16])=[O:6])=[N:8][N:9]([CH3:15])[CH:10]=1

참가 물질

4

반응물 1

HCID 70115754N-(2-Hydroxy-2-methylpropyl)-N,1-dimethyl-4-nitro-1H-pyrazole-3-carboxamide

생성물 1

HCID 793845594-Amino-N-(2-hydroxy-2-methylpropyl)-N,1-dimethyl-1H-pyrazole-3-carboxamide수율 94%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of N-(2-hydroxy-2-methylpropyl)-N,1-dimethyl-4-nitro-1H-pyrazole-3-carboxamide (1.2 g, 4.7 mmol) in ethanol (30 ml) was flushed with argon and treated with palladium on carbon 10% (120 mg, 1.13 mmol). The reaction mixture was evacuated and flushed with hydrogen and stirred at ambient temperature for 16 h. The reaction mixture was filtered, washed with ethanol and concentrated in vacuo to yield the product as dark red oil (1.0 g, 80%) which was used without any further purification.

후처리

  1. customThe reaction mixture was evacuated
  2. customflushed with hydrogen
  3. filtrationThe reaction mixture was filtered
  4. washwashed with ethanol
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-db43834ca35e43fa9989b438790a7927
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623866B2

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