N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide → N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide

HRID 467963노트

반응식

HRID 467963 반응식
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]([F:30])([F:29])[F:28])[CH:21]=2)[C:8]([C:10]2[N:11]=[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]3[CH:18]=2)=[O:9])[CH2:3][CH2:2]1>[C].[Pd].CO>[O:1]1[CH2:6][CH2:5][CH:4]([N:7]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]([F:28])([F:29])[F:30])[CH:21]=2)[C:8]([C:10]2[N:11]=[C:12]3[CH2:17][CH2:16][CH2:15][CH2:14][N:13]3[CH:18]=2)=[O:9])[CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 58049370N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide

생성물 1

HCID 46916730N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide수율 95.1%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

A mixture of N-(tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide (50 mg), 10% palladium-carbon (50 mg) and methanol (15 mL) was stirred in a nitrogen atmosphere for 2 hours at room temperature. The insoluble matter was filtered off and methanol was distilled off under reduced pressure to give the titled compound (48 mg).

후처리

  1. filtrationThe insoluble matter was filtered off
  2. distillationmethanol was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-d15a8106b1404230a679aa89ae608dfc
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623898B2

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