Fluprostenol → HCID 178459548, 화합물

HRID 468036

반응식

HRID 468036 반응식
[CH2:1]1[C@@H:5]([OH:6])[C@H:4](/[CH:7]=[CH:8]/[C@@H:9]([OH:22])[CH2:10][O:11][C:12]2[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][CH:13]=2)[C@@H:3]([CH2:23]/[CH:24]=[CH:25]\[CH2:26][CH2:27][CH2:28][C:29]([OH:31])=[O:30])[C@H:2]1[OH:32].[NH2:33][C@H:34]([C:43]([OH:45])=[O:44])[CH2:35][CH2:36][CH2:37][CH2:38][NH:39][C:40]([NH2:42])=[NH:41]>CO.O>[CH3:35][CH:34]([O:30][C:29]([CH2:28][CH2:27][CH2:26]/[CH:25]=[CH:24]\[CH2:23][C@@H:3]1[C@@H:4](/[CH:7]=[CH:8]/[C@@H:9]([OH:22])[CH2:10][O:11][C:12]2[CH:13]=[CH:14][CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=2)[C@H:5]([OH:6])[CH2:1][C@@H:2]1[OH:32])=[O:31])[CH3:43].[NH2:33][C@H:34]([C:43]([OH:45])=[O:44])[CH2:35][CH2:36][CH2:37][CH2:38][NH:39][C:40]([NH2:42])=[NH:41]

참가 물질

4

반응물 2

HCID 5311100FluprostenolHCID 178512822HCID 178512822, 화합물

생성물 1

HCID 178459548HCID 178459548, 화합물

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

To travoprost free acid ((+)-fluprostenol free acid) 3 in MeOH/H2O is added L-Homoarginine and the solution is stirred for 30 minutes. The solvents are evaporated then azeotroped with Et2O and hexanes to give white crystalline travoprost-L-Homoarginine salt 5 (quantitative).

후처리

  1. customThe solvents are evaporated
  2. customthen azeotroped with Et2O and hexanes

출처 및 근거

ORD 기록
ord-329ac80dce504053b0ad51bc4eddee3d
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623918B2

연결된 노트

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