Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol → Quinidinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol | HCID 5953 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | Fluoreneone | HCID 22281833 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Quinidinone | HCID 84497 | — |
반응 단계
A solution of fluorenone ketyl was prepared by mixing 9 g. of fluorenone and 6.5 g. of sodium in anhydrous toluene. To this solution was added a hot solution of 37 g. of anhydrous quinidine base in 150 ml. of anhydrous toluene. After 15 minutes at reflux, the reaction was complete. After extraction and neutralization treatments as in Example I, 36 g. of pure quinidinone (TLC) was obtained (97% of theory).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04175192 |
| 출처 데이터셋 | uspto-grants-1979_11 |
| ORD ID | ord-2e349f16a0ab4c7baaf37321e4e4dae6 |
| 출처 메모 | uspto-grants-1979_11 |