Benzamide, 2-(hydroxyphenylmethyl)-N-methyl- → 3-Phenylphthalide
반응식
[OH:1][CH:2]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]1[C:4]([C:9](NC)=[O:10])=[CH:5][CH:6]=[CH:7][CH:8]=1>ClC1C=CC=CC=1Cl>[C:13]1([CH:2]2[C:3]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:9](=[O:10])[O:1]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1참가 물질
3
실험 절차
A mixture of 76.5 g. of α-hydroxy-N-methyl-α-phenyl-o-toluamide and (0.314 mole) 150 ml. o-dichlorobenzene is heated at reflux for 18 hours. The mixture is cooled and filtered and the resulting solid triturated with cold ether to give 3-phenyl phthalide.
후처리
- additionA mixture of 76.5 g
- temperatureat reflux for 18 hours
- temperatureThe mixture is cooled
- filtrationfiltered
- customthe resulting solid triturated with cold ether
출처 및 근거
- ORD 기록
- ord-4b3c7438c38d418da5e52322298dbec5
- 출처 데이터셋
- uspto-grants-1979_11
- 특허 번호
- US04175191
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