Benzamide, 2-(hydroxyphenylmethyl)-N-methyl- → 3-Phenylphthalide

HRID 46809

반응식

HRID 46809 반응식
[OH:1][CH:2]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]1[C:4]([C:9](NC)=[O:10])=[CH:5][CH:6]=[CH:7][CH:8]=1>ClC1C=CC=CC=1Cl>[C:13]1([CH:2]2[C:3]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:9](=[O:10])[O:1]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

3

반응물 1

HCID 12241019Benzamide, 2-(hydroxyphenylmethyl)-N-methyl-

생성물 1

HCID 953653-Phenylphthalide

시약·촉매·용매 1

HCID 72391,2-Dichlorobenzene용매

실험 절차

A mixture of 76.5 g. of α-hydroxy-N-methyl-α-phenyl-o-toluamide and (0.314 mole) 150 ml. o-dichlorobenzene is heated at reflux for 18 hours. The mixture is cooled and filtered and the resulting solid triturated with cold ether to give 3-phenyl phthalide.

후처리

  1. additionA mixture of 76.5 g
  2. temperatureat reflux for 18 hours
  3. temperatureThe mixture is cooled
  4. filtrationfiltered
  5. customthe resulting solid triturated with cold ether

출처 및 근거

ORD 기록
ord-4b3c7438c38d418da5e52322298dbec5
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175191

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