Oxalyl chloride → HCID 59625913, 화합물

HRID 468126노트

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HRID 468126 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][O:6][C:7]1[CH:15]=[CH:14][C:10]([C:11](O)=[O:12])=[CH:9][C:8]=1[Cl:16].C(Cl)(=O)C([Cl:23])=O>C1COCC1.CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][O:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([Cl:23])=[O:12])=[CH:9][C:8]=1[Cl:16]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 8707028HCID 8707028, 화합물

생성물 1

HCID 59625913HCID 59625913, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of compound 27d (67 mg, 0.33 mmol) in THF (2 mL) was added oxalyl dichloride (43 μL, 0.50 mmol) dropwise at 0° C., followed by the addition of 2 drops of DMF. The resultant mixture was stirred at 0° C. for 3 h, and then was warmed up to room temperature over 18 h. The solvents were removed under reduced pressure. The resultant residue, crude compound 27e, was dried under reduced pressure for 2 h and used in the following step without further purification.

후처리

  1. customThe solvents were removed under reduced pressure
  2. dry with materialThe resultant residue, crude compound 27e, was dried under reduced pressure for 2 h
  3. customused in the following step without further purification

출처 및 근거

ORD 기록
ord-d57f44e76817401199dececd550be7c8
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623858B2

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