Piperidine → HCID 178501989, 화합물

HRID 46823

반응식

HRID 46823 반응식
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]([O:11][CH3:12])=[O:10])[N+:5]([O-:13])=[C:4]([NH:14][C:15]([O:17][CH3:18])=[O:16])[CH:3]=1.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>C(Cl)Cl>[N:19]1([C:2]2[N:7]=[C:6]([NH:8][C:9]([O:11][CH3:12])=[O:10])[N+:5]([O-:13])=[C:4]([NH:14][C:15]([O:17][CH3:18])=[O:16])[CH:3]=2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 178501976HCID 178501976, 화합물

생성물 1

HCID 178501989HCID 178501989, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A suspension of 7.5 g. of dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide in 35 ml. of methylene chloride is treated with 14.5 ml. of piperidine and the mixture is stirred at room temperature under an argon atmosphere for 18 hours. The white precipitate formed is filtered off and recrystallized from a mixture of methylene chloride and methanol, there being obtained pure dimethyl 6-piperidino-2,4-pyrimidine-dicarbamate-3-oxide, having a melting point of 202° C. (decomposition).

후처리

  1. additionA suspension of 7.5 g
  2. customThe white precipitate formed
  3. filtrationis filtered off
  4. customrecrystallized from a mixture of methylene chloride and methanol, there

출처 및 근거

ORD 기록
ord-cb980e29b6014349a7dfd3002a3011e4
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175190

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