참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-tert-Butyl-1H-indole | HCID 594166 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-(tert-Butyl)indoline | HCID 4642643 | 116.5% |
반응 단계
To a solution of 2-tert-butyl-1H-indole (10 g, 48 mmol) in AcOH (40 mL) was added NaBH4 at 10° C. The mixture was stirred for 20 minutes at 10° C. before being treated dropwise with H2O under ice cooling. The mixture was extracted with ethyl acetate. The combined organic layers were dried over anhydrous Na2SO4, filtered, and concentrated under vacuum to give 2-tert-butylindoline (9.8 g), which was used directly in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08623905B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_01 |
|---|
| ORD ID | ord-ef6a4cefa9ac48f09e6df065def70b07 |
|---|
| 출처 메모 | uspto-grants-2014_01 |
|---|
