(2R)-4-{5-Fluoro-2-oxo-4-[3-(1,3-thiazol-2-yloxy)phenyl]pyridin-1(2H)-yl}-2-methyl-2-(methylsulfonyl)butanoic acid → (2R)-4-{5-Fluoro-2-oxo-4-[3-(1,3-thiazol-2-yloxy)phenyl]pyridin-1(2H)-yl}-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

반응식

[F:1][C:2]1[C:3]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]3[S:28][CH:29]=[CH:30][N:31]=3)[CH:21]=2)=[CH:4][C:5](=[O:19])[N:6]([CH2:8][CH2:9][C@@:10]([CH3:18])([S:14]([CH3:17])(=[O:16])=[O:15])[C:11]([OH:13])=O)[CH:7]=1.FC1C(C2C=CC(N3N=CC=N3)=CC=2)=CC(=O)N(CC[C@@](C)(S(C)(=O)=O)C([NH:44][O:45][CH:46]2[CH2:51][CH2:50][CH2:49][CH2:48][O:47]2)=O)C=1>>[F:1][C:2]1[C:3]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]3[S:28][CH:29]=[CH:30][N:31]=3)[CH:21]=2)=[CH:4][C:5](=[O:19])[N:6]([CH2:8][CH2:9][C@@:10]([CH3:18])([S:14]([CH3:17])(=[O:16])=[O:15])[C:11]([NH:44][O:45][CH:46]2[CH2:51][CH2:50][CH2:49][CH2:48][O:47]2)=[O:13])[CH:7]=1