Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 4-(1-bromoethyl)-N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | N-(7-(5-amino-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide | HCID 67974803 | — |
| 반응물 | 4-(1-Bromoethyl)benzoyl chloride | HCID 86674938 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(1-bromoethyl)-N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)benzamide | HCID 86674939 | — |
반응 단계
To a solution of N-(7-(5-amino-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide (51.8 mg, 0.163 mmol) and pyridine (0.05 mL, 0.6 mmol) in 2 mL dichloromethane was added a solution of the residue from Step 1 in 2 mL dichloromethane. The resulting mixture was stirred at room temperature for 1.5 hours, and then carried forward without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08623889B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-96f39c5e93524d099839f12765c88f15 |
| 출처 메모 | uspto-grants-2014_01 |