참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Dimethylacetamide | HCID 31374 | — |
| 반응물 | 5-Chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one | HCID 104607 | — |
| 반응물 | Benzenamine, N-(3-chloropropyl)-2-nitro- | HCID 10775026 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 20385595 | HCID 20385595 | 78.3% |
반응 단계
A mixture of 43 parts of N-(3-chloropropyl)-2-nitrobenzenamine 47.8 parts of 5-chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one, 30.3 parts of N,N-diethylethanamine and 180 parts of N,N-dimethylacetamide is stirred and heated for 6 hours at 100° C. The reaction mixture is cooled and poured onto 1500 parts of water. The precipitated product is filtered off, washed with water and with 2,2'-oxybispropane and dried, yielding 64 parts (78.3%) of 5-chloro-1,3-dihydro-1-{1-[3-(2-nitrophenylamino)propyl]-4-piperidinyl}-2H-benzimidazol-2-one; mp. 220° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04175129 |
|---|
| 출처 데이터셋 | uspto-grants-1979_11 |
|---|
| ORD ID | ord-8e74c7bb48dc47afa18aac8d1378e893 |
|---|
| 출처 메모 | uspto-grants-1979_11 |
|---|
