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Trifluoroacetic acid → HCID 86712428, 화합물

HRID 469034
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HRID 469034 반응식
[C:1](O)([C:3]([F:6])([F:5])[F:4])=[O:2].[NH:8]1[CH2:12][CH2:11][N:10]=[C:9]1[C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH2:21])=[CH:15][CH:14]=1.[CH3:22][O:23][C:24]1[CH:29]=[C:28]([CH3:30])[C:27]([S:31]([N:34]([CH3:45])[CH:35]([C:37]2[O:41][CH:40]=[C:39]([C:42](O)=[O:43])[CH:38]=2)[CH3:36])(=[O:33])=[O:32])=[C:26]([CH3:46])[CH:25]=1.CCN=C=NCCCN(C)C.C1C=C2N=NN(O)C2=CC=1.O>CN(C=O)C>[F:4][C:3]([F:6])([F:5])[C:1]([NH2:8])=[O:2].[NH:10]1[CH2:11][CH2:12][N:8]=[C:9]1[C:13]1[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][NH:21][C:42]([C:39]2[CH:38]=[C:37]([CH:35]([N:34]([S:31]([C:27]3[C:26]([CH3:46])=[CH:25][C:24]([O:23][CH3:22])=[CH:29][C:28]=3[CH3:30])(=[O:33])=[O:32])[CH3:45])[CH3:36])[O:41][CH:40]=2)=[O:43])=[CH:17][CH:18]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 6422Trifluoroacetic acidHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 27960291-Hydroxybenzotriazole hydrateHCID 223907052-[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]ethan-1-amineHCID 58393040HCID 58393040, 화합물

생성물 1

HCID 86712428HCID 86712428, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The title compound was prepared according to general procedure AH using the bis TFA salt of 2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethanamine, (40 mg, 0.1 mmol), TEA (0.05 mL, 0.32 mmol), DMF (1 mL), 5-(1-{[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}ethyl)furan-3-carboxylic acid (39 mg, 0.11 mmol), EDCI (24 mg, 0.13 mmol) and HOBt monohydrate (17 mg, 0.13 mmol). The crude product was purified using MP-TsOH resin, washing with MeOH (5 mL) and eluting with 7N NH3 in MeOH (7 mL). A portion of the resulting partially purified product was purified using prep method C to afford the title compound.

후처리

  1. customThe title compound was prepared
  2. customThe crude product was purified
  3. washwashing with MeOH (5 mL)
  4. washeluting with 7N NH3 in MeOH (7 mL)
  5. customA portion of the resulting partially purified product was purified

출처 및 근거

ORD 기록
ord-e2bd8799acfa4afebb10c900752ce5eb
출처 데이터셋
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08623859B2

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