Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl Isobutyl Ketone → 1-{1-[3-(1H-benzimidazol-1-yl)propyl]-4-piperidinyl}-5-chloro-1,3-dihydro-2H-benzimidazol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl Isobutyl Ketone | HCID 7909 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 5-Chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one | HCID 104607 | — |
| 반응물 | 1-(3-Chloropropyl)-1H-benzimidazole | HCID 13105517 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-{1-[3-(1H-benzimidazol-1-yl)propyl]-4-piperidinyl}-5-chloro-1,3-dihydro-2H-benzimidazol-2-one | HCID 20385579 | 14% |
반응 단계
A mixture of 9 parts of 1-(3-chloropropyl)-1H-benzimidazole, 10 parts of 5-chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one, 7.4 parts of sodium carbonate and 200 parts of 4-methyl-2-pentanone is stirred and refluxed overnight. The reaction mixture is cooled, water is added and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is crystallized from 4-methyl-2-pentanone, yielding 2.9 parts (14%) of 1-{1-[3-(1H-benzimidazol-1-yl)propyl]-4-piperidinyl}-5-chloro-1,3-dihydro-2H-benzimidazol-2-one; mp. 224° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04175129 |
| 출처 데이터셋 | uspto-grants-1979_11 |
| ORD ID | ord-e14ae101c17d401ab38a545c8ba86135 |
| 출처 메모 | uspto-grants-1979_11 |