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4-[2-(Pyrrolidin-1-yl)ethyl]piperidine → Ammonia

HRID 469099
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HRID 469099 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][C:19]([C:21]([O:23]C)=O)=[N:18][N:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:25])[CH:4]=1.[N:26]1([CH2:31][CH2:32][CH:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[CH2:30][CH2:29][CH2:28][CH2:27]1.C[Al](C)C>ClCCCl>[NH3:13].[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH3:14])[CH2:15][C:16]2[O:20][C:19]([C:21]([N:36]3[CH2:35][CH2:34][CH:33]([CH2:32][CH2:31][N:26]4[CH2:30][CH2:29][CH2:28][CH2:27]4)[CH2:38][CH2:37]3)=[O:23])=[N:18][N:17]=2)(=[O:12])=[O:11])=[C:5]([CH3:25])[CH:4]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 2962934-[2-(Pyrrolidin-1-yl)ethyl]piperidineHCID 16682925TrimethylaluminumHCID 67217606Methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazole-2-carboxylate

생성물 2

HCID 222AmmoniaHCID 461761534-Methoxy-N,2,6-trimethyl-N-[(5-{[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl}-1,3,4-oxadiazol-2-yl)methyl]benzenesulfonamide

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

The title compound was prepared according to general procedure AT using methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazole-2-carboxylate (30 mg, 0.08 mmol), 4-[2-(pyrrolidin-1-yl)ethyl]piperidine (29 mg, 0.16 mmol) and trimethylaluminium (2 M in toluene, 0.08 mL) in DCE (5 mL). The crude product was purified twice using FCC, eluting with 95:4.5:0.5 and 98:2:0.5 DCM:MeOH:NH3, to afford the title compound.

후처리

  1. customThe title compound was prepared
  2. customThe crude product was purified twice using FCC
  3. washeluting with 95:4.5:0.5 and 98:2:0.5 DCM

출처 및 근거

ORD 기록
ord-e122a0c65da54671966046d7314c1572
출처 데이터셋
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08623859B2

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