Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[(1-Methylpiperidin-3-yl)methyl]piperazine → Ammonia
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[(1-Methylpiperidin-3-yl)methyl]piperazine | HCID 2736940 | — |
| 반응물 | Trimethylaluminum | HCID 16682925 | — |
| 반응물 | ethyl 3-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,2,4-oxadiazole-5-carboxylate | HCID 58393317 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | Ammonia | HCID 222 | — |
| 생성물 | HCID 46175636 | HCID 46175636 | — |
반응 단계
The title compound was prepared according to general procedure AT using ethyl 3-({cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,2,4-oxadiazole-5-carboxylate (30 mg, 0.07 mmol), 1-[(1-methylpiperidin-3-yl)methyl]piperazine (31 mg, 0.14 mmol) and trimethylaluminium (2 M in toluene, 0.07 mL) in DCE (5 mL). A portion of the crude product was purified using prep method C, then FCC, eluting with 95:4.5:0.5 DCM:MeOH:NH3, to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08623859B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-baddecc26687458c938461b51db750d1 |
| 출처 메모 | uspto-grants-2014_01 |