Ammonia → 2,6-Dichloro-5-nitropyrimidin-4-amine

HRID 469183

반응식

HRID 469183 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([Cl:12])[N:3]=1.CC[N:15](CC)CC.N>C1COCC1>[NH2:15][C:6]1[N:7]=[C:2]([Cl:1])[N:3]=[C:4]([Cl:12])[C:5]=1[N+:9]([O-:11])=[O:10]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 8471TriethylamineHCID 42978432,4,6-Trichloro-5-nitropyrimidine

생성물 1

HCID 3508112,6-Dichloro-5-nitropyrimidin-4-amine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

A solution of 2,4,6-trichloro-5-nitropyrimidine (94 mg, 0.413 mmol) in THF (5 mL) was cooled to −78° C. and treated with Et3N (110 μL, 0.757 mmol), followed by NH3 (7 N in MeOH, 50 μL, 0.344 mmol). The reaction was warmed to 0° C. Once TLC indicated complete consumption of the starting material, the crude product solution was immediately used in the reaction below (Scheme 40).

후처리

  1. customconsumption of the starting material
  2. customthe crude product solution was immediately used in the reaction below (Scheme 40)

출처 및 근거

ORD 기록
ord-78d78ece27574972ab7b607ff3724d01
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629142B2

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