Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → (4-Benzyloxy-3,5-dimethyl-phenyl)-(6-chloro-pyrimidin-4-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4,6-Dichloropyrimidine | HCID 70943 | — |
| 반응물 | 4-(Benzyloxy)-3,5-dimethylbenzaldehyde | HCID 563557 | — |
| 반응물 | 1,3-Dimethyl-1H-benzimidazol-3-ium iodide | HCID 11821793 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (4-Benzyloxy-3,5-dimethyl-phenyl)-(6-chloro-pyrimidin-4-yl)-methanone | HCID 58181140 | — |
반응 단계
150 mg (1.00 mmol) 4,6-dichloropyrimidine, 367 mg (1.50 mmol) 4-benzyloxy-3,5-dimethylbenzaldehyde and 166 mg (0.600 mmol) 1,3-dimethyl-3H-benzimidazol-1-ium-iodide (Chem. Pharm. Bull. 1990, 1147-52) in 10.0 mL THF were stirred at RT. Then 73.0 mg (1.51 mmol) sodium hydride (50% in mineral oil) were added and the reaction mixture was refluxed for 2.5 h. The reaction mixture was added to ice water and extracted with DCM. The organic phase was dried and evaporated down.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08629137B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-2b99befe98664d19803e34af9b5504b7 |
| 출처 메모 | uspto-grants-2014_01 |