Thionyl Chloride → 4-Cyano-3-fluorobenzoyl chloride

HRID 469341노트

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HRID 469341 반응식
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][C:4]=1[F:12])#[N:2].S(Cl)([Cl:15])=O>>[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([Cl:15])=[O:8])=[CH:5][C:4]=1[F:12])#[N:2]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 27784684-Cyano-3-fluorobenzoic acid

생성물 1

HCID 199567394-Cyano-3-fluorobenzoyl chloride

실험 절차

0.66 g (4.0 mmol) 4-cyano-3-fluoro-benzoic acid were mixed with 10 mL thionyl chloride and boiled for 2 h. The mixture was evaporated to dryness and coevaporated twice with toluene. The residue was reacted further as the crude product.

후처리

  1. customThe mixture was evaporated to dryness
  2. customThe residue was reacted further as the crude product

출처 및 근거

ORD 기록
ord-5d904c35d39c4e24855c8b7d93a46084
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629137B2

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