Methyl 3-amino-2-thiophenecarboxylate → HCID 58557000, 화합물

HRID 469451노트

반응식

HRID 469451 반응식
C([C:3](Br)([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4]([OH:6])=[O:5])C.[NH2:14][C:15]1[CH:19]=[CH:18][S:17][C:16]=1[C:20]([O:22][CH3:23])=[O:21]>C(#N)C>[CH3:23][O:22][C:20]([C:16]1[S:17][CH:18]=[CH:19][C:15]=1[NH:14][CH:3]([C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)[C:4]([OH:6])=[O:5])=[O:21]

참가 물질

4

반응물 2

HCID 89652Methyl 3-amino-2-thiophenecarboxylateHCID 19431595Ethyl 2-bromo-2-phenylacetic acid

생성물 1

HCID 58557000HCID 58557000, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of ethyl 2-bromo-2-phenylacetic acid (600 mg, 2.79 mmol) and methyl 3-aminothiophene-2-carboxylate (438 mg, 2.79 mmol) in acetonitrile (20 ml) was heated under microwave irradiation at 100° C. for 1 hour. Acetonitrile was evaporated to dryness and the resulting residue was used in the next step without any further purification.

후처리

  1. customAcetonitrile was evaporated to dryness
  2. customthe resulting residue was used in the next step without any further purification

출처 및 근거

ORD 기록
ord-2852a2337e8d4caaa243ffaee22e39b6
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629160B2

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