Phenylboronic Acid → HCID 58557000, 화합물

HRID 469453노트

반응식

HRID 469453 반응식
[C:1]1(B(O)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:10][C:11]1[CH:15]=[CH:14][S:13][C:12]=1[C:16]([O:18][CH3:19])=[O:17].O.O=[CH:22][C:23]([OH:25])=[O:24]>C(#N)C>[CH3:19][O:18][C:16]([C:12]1[S:13][CH:14]=[CH:15][C:11]=1[NH:10][CH:22]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:23]([OH:25])=[O:24])=[O:17]

참가 물질

5

반응물 3

HCID 66827Phenylboronic AcidHCID 89652Methyl 3-amino-2-thiophenecarboxylateHCID 15620607Glyoxylic acid, monohydrate

생성물 1

HCID 58557000HCID 58557000, 화합물수율 82%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of phenylboronic acid (286 mg, 2.35 mmol), methyl 3-aminothiophene-2-carboxylate (369 mg, 2.35 mmol), and 2-oxoacetic acid hydrate (216 mg, 2.35 mmol) in acetonitrile (20 ml) was stirred at room temperature for 2 hours. The reaction was filtered, and the precipitated was washed with little acetonitrile. The solution was concentrated under reduced pressure, and the precipitate was collected again by filtration, washing with little acetonitrile. The combined precipitates were dried under vacuum overnight to obtain 2-(2-(methoxycarbonyl)thiophen-3-ylamino)-2-phenylacetic acid (558 mg, 82% yield).

후처리

  1. filtrationThe reaction was filtered
  2. washthe precipitated was washed with little acetonitrile
  3. concentrationThe solution was concentrated under reduced pressure
  4. filtrationthe precipitate was collected again by filtration
  5. washwashing with little acetonitrile
  6. customThe combined precipitates
  7. customwere dried under vacuum overnight

출처 및 근거

ORD 기록
ord-4ac5e791d35f477e9179ddd7d73f9299
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629160B2

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