Aniline → 2-(Benzo[b]thiophen-7-yl)-2-(phenylamino)acetic acid
반응식
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[C:9](B(O)O)[C:2]1=2.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.O.O=[CH:22][C:23]([OH:25])=[O:24]>CC#N>[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[C:9]([CH:22]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:23]([OH:25])=[O:24])[C:2]1=2참가 물질
5
실험 절차
A mixture of benzo[b]thiophen-7-ylboronic acid (300 mg, 1.68 mmol), aniline (157 mg, 1.68 mmol), and 2-oxoacetic acid hydrate (155 mg, 1.68 mmol) in CH3CN (20 ml) was stirred at room temperature for 2 hours. The solvent was evaporated and the crude was purified by flash chromatography (DCM/MeOH=9/1) to obtain 2-(benzo[b]thiophen-7-yl)-2-(phenylamino)acetic acid (303 mg, 63.5% yield).
후처리
- customThe solvent was evaporated
- customthe crude was purified by flash chromatography (DCM/MeOH=9/1)
출처 및 근거
- ORD 기록
- ord-b0b765b6764c4e89aa545c36aae88dc5
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08629160B2
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