2-(5-chlorothiophen-2-yl)acetic Acid → 2-(5-chloro-2-thienyl)-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide

참여 물질

역할	이름	HCID	투입량
반응물	2-(5-chlorothiophen-2-yl)acetic Acid	HCID 4426716	—
반응물	2-amino-4-(trifluoromethyl)phthalazin-1(2H)-one	HCID 67161111	—
생성물	2-(5-chloro-2-thienyl)-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide	HCID 67160460	—

반응 단계

The product of Example 11B and 2-(5-chlorothiophen-2-yl)acetic acid were treated using a method similar to that described in Example 5 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.96-11.98 (bs, 1H), 8.43 (d, J=8.4 Hz, 1H), 8.11-8.17 (m, 1H), 7.97-8.10 (m, 2H), 7.01 (d, J=3.8 Hz, 1H), 6.93 (d, J=3.8 Hz, 1H), 3.96 (d, J=0.8 Hz, 2H); MS (ESI) m/z 388 (M+H)+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08629143B2
출처 데이터셋	uspto-grants-2014_01
ORD ID	ord-504f916a9ec141e880d3ab927e747ed1
출처 메모	uspto-grants-2014_01