(4-Chlorophenyl)acetic acid → HCID 67161415, 화합물

반응식

[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](O)=[O:29])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:19])=[O:29])=[CH:23][CH:22]=1

참가 물질

반응물 2

HCID 15880(4-Chlorophenyl)acetic acid

HCID 67160366HCID 67160366, 화합물

생성물 1

HCID 67161415HCID 67161415, 화합물

실험 절차

The product of Example 125A and 2-(4-chlorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.74 (s, 1H), 8.39-8.42 (m, 1H), 7.90-8.05 (m, 2H), 7.68-7.74 (m, 1H), 7.55-7.67 (m, 4H), 7.35-7.46 (m, 4H), 3.71 (s, 2H); MS (ESI+) m/z 424 (M+H)+.

출처 및 근거

ORD 기록: ord-b3c42623b7f748e69b259af6178f1c45
출처 데이터셋: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08629143B2

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