3,5-Difluorophenylacetic acid → HCID 67160072, 화합물

HRID 469628노트

반응식

HRID 469628 반응식
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[F:20][C:21]1[CH:22]=[C:23]([CH2:28][C:29](O)=[O:30])[CH:24]=[C:25]([F:27])[CH:26]=1>>[F:20][C:21]1[CH:22]=[C:23]([CH2:28][C:29]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:19])=[O:30])[CH:24]=[C:25]([F:27])[CH:26]=1

참가 물질

3

반응물 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67160399HCID 67160399, 화합물

생성물 1

HCID 67160072HCID 67160072, 화합물

실험 절차

The product of Example 129A and 2-(3,5-difluorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.77-11.79 (bs, 1H), 8.40-8.43 (m, 1H), 7.90-8.03 (m, 2H), 7.69-7.74 (m, 1H), 7.63-7.69 (m, 2H), 7.38-7.43 (m, 2H), 7.06-7.21 (m, 3H), 3.77-3.78 (bs, 2H); MS (APCI+) M/Z 410 (M+H)+.

출처 및 근거

ORD 기록
ord-476b3c89d1704e4f93a916329c5225d2
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629143B2

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