Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Carbon tetrabromide → tert-Butyl 3-bromopropionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Carbon tetrabromide | HCID 11205 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | tert-Butyl 3-hydroxypropanoate | HCID 16218743 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | tert-Butyl 3-bromopropionate | HCID 256128 | — |
반응 단계
3-Hydroxy-propionic acid tert-butyl ester is dissolved in acetonitrile and carbon tetrabromide and triphenylphosphine is added. The mixture is stirred at room temperature overnight. After this time the mixture is concentrated in vacuo. The gummy solid is triturated with hexanes and the liquid decanted, passed through pad of silica to remove any triphenylphosphine oxide, and concentrated in vacuo. 1H NMR (400 MHz, CHLOROFORM-d) ppm 1.3 (9H, s), 2.06-2.27 (2H, m), 4.07-4.25 (2H, m).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08629157B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-dcb257f0551e46a2852671ecd9f8e2c7 |
| 출처 메모 | uspto-grants-2014_01 |