Ethyl Acetate → HCID 21812870, 화합물
반응식
[NH2:1]/[C:2](/[C:6]([CH3:9])([CH3:8])[CH3:7])=[CH:3]\[C:4]#[N:5].O.O.O.O.O.O.O.O.O.O.[S-2:20].[Na+].[Na+].C(OCC)(=O)C>[Cl-].C([N+](CCCC)(CCCC)CCCC)CCC.C1C=CC=CC=1.O>[NH2:1]/[C:2](/[C:6]([CH3:9])([CH3:8])[CH3:7])=[CH:3]\[C:4](=[S:20])[NH2:5]참가 물질
7
실험 절차
(Z)-3-amino-4,4-dimethyl-pent-2-enenitrile (26 g, 209.35 mmol), sodium sulfide decahydrate (5.71 g, 73.27 mmol) and tetrabutyl ammonium chloride (9.31 g, 33.49 mmol) in benzene and water (215 mL, 2.5:1, v/v) is stirred at 75° C. under hydrogen sulfide gas for three days. 200 mL of ethyl acetate is added and the layers separated. The organic layer is washed with water, dried over sodium sulfate, filtered and concentrated under reduced pressure to afford the title compound. Yield 23% over three steps. ESI m/z 159=MH+
후처리
- customthe layers separated
- washThe organic layer is washed with water
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-3730f2159afd4d9ebc6d4a3b7243e6e7
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08629157B2
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