(3-Methyl-1,2,4-oxadiazol-5-yl)methanamine → 5-cyclohexyl-N-(3-methyl-[1,2,4]oxadiazol-5-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 469785노트

반응식

HRID 469785 반응식
[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([OH:14])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:22][C:23]1[N:27]=[C:26]([CH2:28][NH2:29])[O:25][N:24]=1>>[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([NH:29][CH2:28][C:26]2[O:25][N:24]=[C:23]([CH3:22])[N:27]=2)=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

3

반응물 2

HCID 10844548(3-Methyl-1,2,4-oxadiazol-5-yl)methanamineHCID 712939525-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

생성물 1

HCID 712942335-cyclohexyl-N-(3-methyl-[1,2,4]oxadiazol-5-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

실험 절차

This compound was prepared following the same procedure as described in Example 11 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 4b) (100 mg, 0.33 mmol) and 3-methyl-1,2,4-oxadiazole-5-methanamine (CAN 90928-92-0) (37 mg, 0.33 mmol) as starting materials; off white solid (30 mg, 22.9%). MS (ESI): 399 (M+H)+.

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-fc4bbee5786045e18ee69b83a88e58fc
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629166B2

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