Tetrahydrofuran → 4-amino-N,N,2-trimethylbenzamide

HRID 469825노트

반응식

HRID 469825 반응식
[CH3:1][C:2]1[CH:12]=[C:11]([N+:13]([O-])=O)[CH:10]=[CH:9][C:3]=1[C:4]([N:6]([CH3:8])[CH3:7])=[O:5].C1COCC1>CO.[Pd]>[NH2:13][C:11]1[CH:10]=[CH:9][C:3]([C:4]([N:6]([CH3:8])[CH3:7])=[O:5])=[C:2]([CH3:1])[CH:12]=1

참가 물질

5

반응물 2

HCID 8028TetrahydrofuranHCID 62604610N,N,2-trimethyl-4-nitrobenzamide

생성물 1

HCID 536229124-amino-N,N,2-trimethylbenzamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 1.7 g (8.16 mmol) 2,N,N-trimethyl-4-nitro-benzamide in 45 ml MeOH:THF=1:1 is hydrogenated in the presence of 0.2 g 10% Pd/C (Fluka 75990). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the crude title compound.

후처리

  1. filtrationThe reaction mixture is filtered (2 glass fiber filters used)
  2. concentrationthe filtrate is concentrated in vacuo

출처 및 근거

ORD 기록
ord-8cd8849841184a608b42eb6ad4f7817e
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629168B2

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