Tetrahydrofuran → 4-[4-(2-Methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenylamine

HRID 469832노트

반응식

HRID 469832 반응식
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][C:12]=2[CH3:20])[CH2:7][CH2:6]1.C1COCC1>CO.[Pd]>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=2[CH3:20])[CH2:7][CH2:6]1

참가 물질

5

반응물 2

HCID 8028TetrahydrofuranHCID 674588251-(2-Methoxy-ethyl)-4-(2-methyl-4-nitro-phenyl)-piperazine

생성물 1

HCID 666173884-[4-(2-Methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenylamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 0.85 g (3.04 mmol) 1-(2-methoxy-ethyl)-4-(2-methyl-4-nitro-phenyl)-piperazine in 20 ml MeOH:THF=1:1 is hydrogenated in the presence of 0.2 g 10% Pd/C (Engelhard 4505). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the title compound as an oil.

후처리

  1. filtrationThe reaction mixture is filtered (2 glass fiber filters used)
  2. concentrationthe filtrate is concentrated in vacuo

출처 및 근거

ORD 기록
ord-5cf1bcbbf98a4561a3630887a21c097b
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629168B2

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