Bromine → HCID 20386067, 화합물

HRID 46985노트

반응식

HRID 46985 반응식
[C:1]([CH2:3][C:4]1[CH:14]=[CH:13][C:7]([CH2:8][CH2:9]C(O)=O)=[CH:6][CH:5]=1)#[N:2].[Br:15]Br>C(Cl)(Cl)(Cl)Cl>[Br:15][CH2:9][CH2:8][C:7]1[CH:13]=[CH:14][C:4]([CH2:3][C:1]#[N:2])=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 20386113p-Cyanomethylhydrocinnamic acid

생성물 1

HCID 20386067HCID 20386067, 화합물

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of p-cyanomethylhydrocinnamic acid (18.9 g., 0.1 mole), red mercuric oxide (17.2 g., 0.08 mole), and carbon tetrachloride (180 ml.) is stirred at room temperature while bromine (16.0 g., 0.1 mole) is added dropwise during 40 minutes. The resulting mixture is heated at reflux for 1 hour. The mixture is then cooled, filtered, washed with dilute hydrochloric acid and water, and dried over magnesium sulfate. The solution is evaporated to leave the product as a yellow residual oil. It is purified by column chromatography on silica gel with benzene elution.

후처리

  1. additionis added dropwise during 40 minutes
  2. temperatureThe resulting mixture is heated
  3. temperatureat reflux for 1 hour
  4. temperatureThe mixture is then cooled
  5. filtrationfiltered
  6. washwashed with dilute hydrochloric acid and water
  7. dry with materialdried over magnesium sulfate
  8. customThe solution is evaporated

출처 및 근거

ORD 기록
ord-6a8b1955e7b246738545bc6c90809a31
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175203

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