1-Propanol → 2,3-Dimethyl-4-propoxypyridine 1-oxide

반응식

[CH3:1][C:2]1[C:7]([CH3:8])=[C:6]([N+]([O-])=O)[CH:5]=[CH:4][N+:3]=1[O-:12].C(=O)([O-])[O-].[K+].[K+].[CH2:19]([OH:22])[CH2:20][CH3:21]>>[CH3:1][C:2]1[C:7]([CH3:8])=[C:6]([O:22][CH2:19][CH2:20][CH3:21])[CH:5]=[CH:4][N+:3]=1[O-:12]

참가 물질

반응물 3

HCID 10311-Propanol

HCID 11430Potassium Carbonate

HCID 1482232,3-Dimethyl-4-nitropyridine-N-oxide

생성물 1

HCID 150355372,3-Dimethyl-4-propoxypyridine 1-oxide

반응 조건

온도: 80 °C

실험 절차

In n-propanol (42 ml) was dissolved 2,3-dimethyl-4-nitropyridine-1-oxide (841 mg). To the solution was added anhydrous potassium carbonate (2.1 g), and the mixture was stirred at 80° C. for 22 hours, followed by filtration with celite. The filtrate was concentrated, and the residue was chromatographed on a column of silica-gel (50 g), which was eluted with 5% methanol.chloroform to yield 2,3-dimethyl-4-propoxypyridine-1-oxide (360 mg) as an oily substance.

후처리

filtrationfollowed by filtration with celite
concentrationThe filtrate was concentrated
customthe residue was chromatographed on a column of silica-gel (50 g), which
washwas eluted with 5% methanol

출처 및 근거

ORD 기록: ord-fcfef2d239354cdaa1521ec40209288e
출처 데이터셋: uspto-grants-1988_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04727150

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