Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene → 3-Chlorobenzophenone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene | HCID 241 | — |
| 반응물 | Benzoyl chloride, 3-chloro- | HCID 69252 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 3-Chlorobenzophenone | HCID 66098 | — |
반응 단계
To a refluxing solution containing 43.9 g (0.25 mole) of 3-chlorobenzoyl chloride in 120 ml. of dry benzene is added 30.0 g. (0.225 mole) of anhydrous aluminum chloride in several portions over a period of 10 minutes. When the reaction is complete, as indicated by vapor phase chromatographic (vpc) techniques, the mixture is cooled to 25° and diluted with ether. Extraction with dilute base is followed by thorough drying (magnesium sulfate) and concentration in vacuo. Final purification is effected by recrystallization from ether-hexane to afford 13.7 g (0.06 mole) of 3-chlorobenzophenone, m.p. 84°14 85°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04175945 |
| 출처 데이터셋 | uspto-grants-1979_11 |
| ORD ID | ord-15a97d0c27f449c78d07e3ae923f3116 |
| 출처 메모 | uspto-grants-1979_11 |