3-Pyrroline → HCID 178501987, 화합물

HRID 47027노트

반응식

HRID 47027 반응식
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]([O:11][CH3:12])=[O:10])[N+:5]([O-:13])=[C:4]([NH:14][C:15]([O:17][CH3:18])=[O:16])[CH:3]=1.[NH:19]1[CH2:23][CH:22]=[CH:21][CH2:20]1>C(Cl)Cl>[N:19]1([C:2]2[N:7]=[C:6]([NH:8][C:9]([O:11][CH3:12])=[O:10])[N+:5]([O-:13])=[C:4]([NH:14][C:15]([O:17][CH3:18])=[O:16])[CH:3]=2)[CH2:23][CH:22]=[CH:21][CH2:20]1

참가 물질

4

반응물 2

HCID 660593-PyrrolineHCID 178501976HCID 178501976, 화합물

생성물 1

HCID 178501987HCID 178501987, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A suspension of 12.5 g. of dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide in 100 ml. of methylene chloride is treated with 15 g. of 3-pyrroline and the mixture is stirred at room temperature under an argon atmosphere for 26 hours. The white precipitate formed is filtered off and recrystallized from a mixture of methylene chloride and methanol, there being obtained pure dimethyl 6-(3-pyrrolin-1-yl)-2,4-pyrimidine-dicarbamate-3-oxide, having a melting point of 206° C. (decomposition).

후처리

  1. additionA suspension of 12.5 g
  2. customThe white precipitate formed
  3. filtrationis filtered off
  4. customrecrystallized from a mixture of methylene chloride and methanol, there

출처 및 근거

ORD 기록
ord-b3d8b6a5e820468e86a650a333843cfa
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04176119

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