HCID 59784811, 화합물 → HCID 59784760, 화합물

HRID 470333노트

반응식

HRID 470333 반응식
NC1C(C(O)=O)=CN(C2N=CC3CC[C:14]4[CH:20]=[C:21]([O:24][CH3:25])C=C[C:13]=4[C:12]=3[N:11]=2)N=1.Br[C:27]1[CH:39]=[CH:38][C:30]2[NH:31]C(C(Cl)(Cl)Cl)=[N:33][C:29]=2[CH:28]=1>CC(N(C)C)=O>[NH2:33][C:29]1[CH:28]=[C:27]([C:20]2[C:21]([O:24][CH3:25])=[N:11][CH:12]=[CH:13][CH:14]=2)[CH:39]=[CH:38][C:30]=1[NH2:31]

참가 물질

4

반응물 2

HCID 59784811HCID 59784811, 화합물HCID 178478477HCID 178478477, 화합물

생성물 1

HCID 59784760HCID 59784760, 화합물

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

A solution of salicylaldehyde derivative 1 (0.5 mmol) and diamine 2 (0.176 g, 0.5 mmol) in dimethylacetamide (4 mL) was stirred at 100° C. for 12 h. Solvent was evaporated and the residue was purified by preparative HPLC to give benzimidazole derivative 3.

후처리

  1. customSolvent was evaporated
  2. customthe residue was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-767a453eef514022b2180d55ee167413
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629147B2

반응 노트

불러오는 중…