tert-Butyl 4-(cyanomethylidene)piperidine-1-carboxylate → tert-Butyl 4-(cyanomethyl)piperidine-1-carboxylate

HRID 470617노트

반응식

HRID 470617 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]#[N:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][C:15]#[N:16])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 15326949tert-Butyl 4-(cyanomethylidene)piperidine-1-carboxylate2회

생성물 1

HCID 22248390tert-Butyl 4-(cyanomethyl)piperidine-1-carboxylate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

4-Cyanomethylene-piperidine-1-carboxylic acid tert-butyl ester (compound of Example 14; 6.9 g, 31.0 mmol) and Pd/C (0.7 g) in ethanol (150 mL) was maintained under hydrogen atmosphere for 8 h. The reaction mixture was filtered through Celite and the solvent was evaporated to afford the title compound.

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-818dcfa918dd4a16a8512cc81129a5aa
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629277B2

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