Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 5,6-Dimethoxy-3[4(2-methylpropyloxycarbonyl)piperazino]methylene oxindole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Isobutyl piperazine-1-carboxylate | HCID 11788701 | — |
| 반응물 | HCID 178486553 | HCID 178486553 | — |
| 용매 | Benzene | HCID 241 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5,6-Dimethoxy-3[4(2-methylpropyloxycarbonyl)piperazino]methylene oxindole | HCID 53951346 | — |
반응 단계
5.00 g. of 5,6-Dimethoxy-3-hydroxymethylene oxindole, 2.5 g. acetic acid and 6.5 g. piperazine-N-carboxylic acid isobutyl ester (U.S. Pat. No. 3,635,979) in 40 ml. benzene was refluxed using a water separator to remove the water as it formed. After 20 minutes, 200 ml. benzene was added and the solution extracted with potassium carbonate and water. The benzene solution was treated with magnesium sulfate and charcoal, filtered, concentrated and the residue crystallized from isopropyl alcohol and ether to give 5.50 g. product, m.p. 195°-197° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04176191 |
| 출처 데이터셋 | uspto-grants-1979_11 |
| ORD ID | ord-72970bca4ce742a8bdfe7b556c92414c |
| 출처 메모 | uspto-grants-1979_11 |