Potassium Hydroxide → Di-(4-methoxyphenyl)methyleneamino-oxyacetic acid

HRID 47082노트

반응식

HRID 47082 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[N:18][O:19][CH2:20][C:21]([O:23]CC)=[O:22])[C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:5][CH:4]=1.[OH-].[K+]>C(O)C.O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[N:18][O:19][CH2:20][C:21]([OH:23])=[O:22])[C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 20385237Ethyl di-(4-methoxyphenyl)methyleneamino-oxyacetate

생성물 1

HCID 12942475Di-(4-methoxyphenyl)methyleneamino-oxyacetic acid수율 55%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A solution of ethyl di-(4-methoxyphenyl)methyleneamino-oxyacetate (1.0 g.) in ethanol (20 ml.) and water (5 ml.) containing potassium hydroxide (1.0 g.) was left at ambient temperature for 16 hours. The solution was evaporated and the residue partitioned between ether and water. The aqueous layer was separated and acidified with concentrated hydrochloric acid. The mixture was extracted with ether, the extract dried (MgSO4) and evaporated to give di-(4-methoxyphenyl)methyleneamino-oxyacetic acid as a solid (0.5 g.), m.p. 105°-107° C. (55% yield).

후처리

  1. customThe solution was evaporated
  2. customthe residue partitioned between ether and water
  3. customThe aqueous layer was separated
  4. extractionThe mixture was extracted with ether
  5. dry with materialthe extract dried (MgSO4)
  6. customevaporated

출처 및 근거

ORD 기록
ord-8dfd16dfa82e4d0dbd6eeb6d14cf08a0
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04176194

반응 노트

불러오는 중…