Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,5-Dimethoxytetrahydrofuran → 4-Phenoxy-3-(1H-pyrrol-1-yl)-5-sulfamoylbenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,5-Dimethoxytetrahydrofuran | HCID 79098 | — |
| 반응물 | 3-Amino-4-phenoxy-5-sulfamoylbenzoic acid | HCID 119927 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-Phenoxy-3-(1H-pyrrol-1-yl)-5-sulfamoylbenzoic acid | HCID 12881131 | — |
반응 단계
A mixture of 3-sulphamoyl-4-phenoxy-5-amino-benzoic acid (3.08 g=10 mmols); P. W. Feit, J. Med. Chem. 14,432 (1971), 2,5-dimethoxy-tetrahydrofurane (1.32 g=10 mmols) and 5 ml of glacial acetic acid is refluxed for 15 minutes in an oil bath and evaporated to dryness in vacuo and the residue is recrystallised from ethyl acetate; the compound melts at 209°-210° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04176190 |
| 출처 데이터셋 | uspto-grants-1979_11 |
| ORD ID | ord-95cb7f59645a4f7aadd008677146636c |
| 출처 메모 | uspto-grants-1979_11 |