Methanol → Benzeneethanol, 3-(bromomethyl)-
반응식
CSC.B.[Br:5][CH2:6][C:7]1[CH:8]=[C:9]([CH2:13][C:14](O)=[O:15])[CH:10]=[CH:11][CH:12]=1.CO>C1COCC1>[Br:5][CH2:6][C:7]1[CH:8]=[C:9]([CH2:13][CH2:14][OH:15])[CH:10]=[CH:11][CH:12]=1참가 물질
5
실험 절차
Borane dimethylsulphide complex (2M solution in THF, 5.78 mL) was added dropwise to a solution of 2-(3-(bromomethyl)phenyl)acetic acid (1.06 g) in THF (10 mL) at 0° C. and the resulting mixture stirred for 10 min. The reaction was then allowed to warm to room temperature and stirred overnight. Methanol (5 mL) was then added and the mixture concentrated in vacuo. Purification was by silica gel chromatography eluting with isohexane to diethyl ether gradient to give the subtitled compound as a white solid. Yield 1 g.
후처리
- stirringstirred overnight
- concentrationthe mixture concentrated in vacuo
- customPurification
- washeluting with isohexane to diethyl ether gradient
출처 및 근거
- ORD 기록
- ord-2ad67469a81d4a00a5fbada5e063f898
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08629271B2
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