Ammonia → 2-(3-(1-Oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-5-fluorophenyl)ethanol

HRID 471108노트

반응식

HRID 471108 반응식
N.[F:2][C:3]1[CH:4]=[C:5]([CH:31]=[C:32]([CH2:34][CH2:35][OH:36])[CH:33]=1)[CH2:6][N:7]1[CH2:30][CH2:29][C:10]2([O:15][CH2:14][CH2:13][N:12](C(C3N=C(C4C=CC=CC=4)SC=3)=O)[CH2:11]2)[CH2:9][CH2:8]1>CO>[O:15]1[C:10]2([CH2:29][CH2:30][N:7]([CH2:6][C:5]3[CH:31]=[C:32]([CH2:34][CH2:35][OH:36])[CH:33]=[C:3]([F:2])[CH:4]=3)[CH2:8][CH2:9]2)[CH2:11][NH:12][CH2:13][CH2:14]1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 57989277(9-(3-Fluoro-5-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-phenylthiazol-4-yl)methanone

생성물 1

HCID 579889902-(3-(1-Oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-5-fluorophenyl)ethanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

‘880’ Ammonia solution (5 mL) was added to a solution of 2,2,2-trifluoro-1-(9-(3-fluoro-5-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)ethanone (example 41, step d) (2.2 g) in methanol (25 mL). The resulting mixture was stirred for 90 min and the solvent evaporated. The residue was azeotroped three times with acetonitrile and concentrated to give the subtitled compound as a clear gum. Yield 1.96 g.

후처리

  1. customthe solvent evaporated
  2. customThe residue was azeotroped three times with acetonitrile
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2960abd10b234dfdbce2f3746f1af1c3
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629271B2

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