2-(4-Chloro-3-(hydroxymethyl)phenyl)ethanol → 2-Chloro-5-(2-hydroxyethyl)benzaldehyde

HRID 471129

반응식

HRID 471129 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][C:3]=1[CH2:11][OH:12]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][C:3]=1[CH:11]=[O:12]

참가 물질

4

반응물 1

HCID 579892912-(4-Chloro-3-(hydroxymethyl)phenyl)ethanol

생성물 1

HCID 579893312-Chloro-5-(2-hydroxyethyl)benzaldehyde

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

Manganese (IV) dioxide (1.00 g) was added to a solution of 2-(4-chloro-3-(hydroxymethyl)phenyl)ethanol (example 61, step b) (0.200 g) in DCM (5 mL), and the resulting suspension was stirred at room temperature overnight. The mixture was then filtered through Celite, washing the residue well with DCM. The filtrate and washings were concentrated in vacuo to afford the subtitled compound as a colourless oil. Yield 0.197 g.

후처리

  1. filtrationThe mixture was then filtered through Celite
  2. washwashing the residue well with DCM
  3. concentrationThe filtrate and washings were concentrated in vacuo

출처 및 근거

ORD 기록
ord-a9012c1578a044dca9dd93736dc3a8ba
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629271B2

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